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Keywords: Depression, Nrf2, Oxidative stress, Neuroinflammation, Autophagy, Ferroptosis Abbreviations ARE antioxidant response elements AA arachidonic acid bZIP basic-region leucine zipper BDNF brain-derived neurotrophic factor BTB bric-a-brac β-TrCP β-transducin repeat-containing protein CREB cAMP response element-binding protein CBP CREB-binding protein CNC Cap'n’collar CK2 Casein kinase II CAT catalase CSF cerebrospinal fluid CSDS chronic social defeat stress CUMS chronic unpredictable mild stress JNK c-Jun N-terminal kinase CRP C-reactive protein Cul3 Cullin 3 DAMPs damage-associated molecular patterns DMF dimethyl fumarate DGR double glycine repeat Drp1 dynamin-related protein 1 ETC electron transport chain ERK extracellular regulated kinases FTH1 ferritin heavy chain 1 FTL1 ferritin light chain 1 GCL glutamate-cysteine ligase GSH glutathione GPX glutathione peroxidase GR glutathione reductase GST glutathione S-transferase GSS glutathione synthetase GSK-3β glycogen synthase kinase-3β HO-1 heme oxygenase 1 IDO indoleamine-pyrrole 2,3-dioxygenase IL interleukin Keap1 Kelch-like ECH-associated protein 1 LIP labile iron pools LC3 light chain 3 LH learned helplessness L-OH lipid alcohols L-OOH lipid hydroperoxides LPS lipopolysaccharide MDD major depressive disorder MDA malondialdehyde mtDNA mitochondrial DNA mPFC medial prefrontal cortex MPTP mitochondrial permeability transition pores MAO monoamine oxidase MAOI monoamine oxidase inhibitor NQO1 NAD(P)H dehydrogenase quinone 1 NF-κB nuclear factor-κB Nrf2 nuclear factor erythroid 2-related factor 2 PRDX peroxiredoxin PPARγ Peroxisome proliferator-activated receptor gamma PGC-1α peroxisome proliferator-activated receptor gamma coactivator alpha PUFA polyunsaturated fatty acids PFC prefrontal cortex PKC Protein kinase C PKR protein kinase R PERK PKR-like endoplasmic reticulum kinase PINK1 PTEN-induced putative kinase 1 MAPK p38 mitogen-activated protein kinases RLS reactive lipid species RNS reactive nitrogen species ROS reactive oxygen species rTMS Repetitive transcranial magnetic stimulation RXRα retinoic X receptor α SSRIs selective serotonin reuptake inhibitors Sirt1 sirtuin-1 sMaf small musculoaponeurotic fibrosarcoma Srx1 sulfiredoxin 1 SOD Superoxide dismutase TRX thioredoxin TrxR thioredoxin reductase TFR1 Transferrin receptor 1 TSPO translocator protein TNF-α tumor necrosis factor-α ULK1 unc-51-like kinase 1 XO xanthine oxidase 4-HNE 4-hydroxy-2-nonenal 5-HT 5-hydroxytryptamine 8-OHdG 8-OH 2-deoxyguanosine 1
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Results Increased cell death after cisplatin treatment is related to higher DNA damage induction The cell sensitivity to cisplatin treatment was evaluated in one normal lung fibroblast cell line (IMR-90) and two NSCLC cell lines (A549 and NCI H23)
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